The Japanese Biochemical Society

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[1T13a-05(P-303)] Identification of 3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine derivatives as novel selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

Hartuti Endah Dwi1,2,3, Takaya Sakura4,5, Mohammed S. O. Tagod5, Eri Yoshida4, Xinying Wang5,6, Kota Mochizuki7, Rajib Acharjee1,2, Fuyuki Tokumasu8, Mihoko Mori9, Danang Waluyo3, Kazuro Shiomi9, Tomoyoshi Nozaki6, Shinjiro Hamano1,2 (1.Program for Nurturing Global Leaders in Tropical and Emerging Communicable Disease, Nagasaki University, 2.Department of Parasitology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 3.Laboratory for Biotechnology, Agency for the Assessment and Application of Technology, Indonesia, 4.Department of Molecular Infection Dynamics, NEKKEN, Nagasaki University, 5.School of Tropical Medicine and Global Health, Nagasaki University, 6.Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7.Department of Immunogenetics, NEKKEN, Nagasaki University, 8.Department of Cellular Architecture Studies, NEKKEN, Nagasaki University, 9.Graduate School of Infection Control Sciences, Kitasato University, 10.Department of Host-Defense Biochemistry, NEKKEN, Nagasaki University)

キーテクノロジー:PfDHODH inhibitors screening

Plasmodium falciparum、dihydroorotate dehydrogenase、inhibitor screening、antimalarial drug

endah.dwi08@yahoo.co.id

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