Nowadays, fluorescence observation is used by many researchers as a "normal" instrument in the research field. However, at COVID-19 calamity, it is becoming increasingly important to understand how to conduct research under time constraints. Therefore, we propose the "new normal of fluorescence microscopy" with the THUNDER imaging system, which is an ordinary fluorescence microscope that can acquire ultra-high-resolution images, focusing on how to make fluorescence observation more efficient and produce maximum results in a limited time.