Impaired glucose-stimulated insulin secretion due to mitochondrial abnormalities in pancreatic beta-cells of 5-aminolevulinate synthase1 (ALAS1) gene knockout heterozygous mice

Kazuya Takeda

5:20 PM - 5:30 PM

[2T14e-03(P-799)] Impaired glucose-stimulated insulin secretion due to mitochondrial abnormalities in pancreatic beta-cells of 5-aminolevulinate synthase1 (ALAS1) gene knockout heterozygous mice

^○Kazuya Takeda^1,2, Koen van Wijk¹, Tomohiro Kimura¹, Satoshi Okano¹, Sinichi Saitho¹, Hiroaki Yamaguchi², Kodama Ken³, Takahashi Kiwamu⁴, Toru Tanaka⁴, Motoo Nakazima⁴, Osamu Nakazima¹ (1.Inst. for Promotion of Med.Sci. Res., Yamagata Univ. Sch. Med., 2.Dep. of Pharmacy, Yamagata Univ. Sch. Med., 3.Neopharm Japan Co., Ltd., 4.SBI Pharmaceuticals Co., Ltd.)

キーテクノロジー：遺伝子破壊マウス

ヘム、5-アミノレブリン酸、インスリン、2型糖尿病、ミトコンドリア

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The 94th Annual Meeting of JBS

[2T14e-03(P-799)] Impaired glucose-stimulated insulin secretion due to mitochondrial abnormalities in pancreatic beta-cells of 5-aminolevulinate synthase1 (ALAS1) gene knockout heterozygous mice

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