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[3S06a-04] Persistent activation of transcription factor NRF2 causes enhancer remodeling which promotes tumor-initiating activity

Keito Okazaki1, Hayato Anzawa2, Yoshinori Okada3, Takashi Suzuki4, Kengo Kinoshita2, Hiroki Sekine1, Hozumi Motohashi1 (1.Ins. Of Dev. Aging and Cancer Tohoku Univ. Dep. of Gene Exp. Reg., 2.Tohoku Univ. Grad. Sch. of Inf. Sci., 3.Ins. Of Dev. Aging and Cancer Tohoku Univ. Dep. of Tho. Sur., 4.Tohoku Univ. Grad. Sch. of Dep. of Ana. Pat.)

キーテクノロジー:RNAシーケンス、ChIPシーケンス

NRF2、CEBPB、NOTCH3、エンハンサーリモデリング、腫瘍幹細胞性

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