10:40 〜 10:50

[3T14m-11(P-171)] Co-crystal structure analysis of Ferulenol derivatives in complex with human dihydroorotate dehydrogenase: a therapeutic target for cancer cells living under tumor microenvironment

^○Tagod Mohammed S. O.¹, Takaya Takaya^1,2, Eri Amalia³, Takahiro Sasagawa³, Osumi Yukiko⁴, Matsui Hiroki⁴, Masuda Ayuna⁴, Yukiko Miyazaki¹, Tomoo Shiba⁴, Hiroyuki Saimoto⁵, Kiyoshi Kita^2,3,6, Daniel Ken Inaoka^1,2,3 (1.Department of Molecular Infection Dynamics, NEKKEN, Nagasaki University, 2.School of Tropical Medicine and Global Health, 3.Department of Biomedical Chemistry, The University of Tokyo, 4.Department of Applied Biology, Kyoto Institute of Technology, 5.Department of Chemistry and Biotechnology, Tottori University, 6.Department of Host-Defense Biochemistry, NEKKEN)

キーテクノロジー：Co-crystallization

HsDHODH