[P-035] Quantification of chondroitin/dermatan/heparan sulfate in knockout zebrafish of b3galt6 responsible for biosynthesis of the linkage region tetrasaccharide of glycosaminoglycans

Sarah Delbaere¹, Adelbert De Clercq¹, ^○Shuji Mizumoto², Fredrik Noborn^3,4, Jan Willem Bek¹, Lien Alluyn¹, Charlotte Gistelinck⁵, Delfien Syx¹, Phil L. Salmon⁶, Paul J. Coucke¹, Goran Larson^3,4, Shuhei Yamada², Andy Willaert¹, Fransiska Malfait¹ (1.Cent. Med. Genet. Ghent, Dept. Biomol. Med., Ghent Univ. and Ghent Univ. Hospit., Ghent, Belgium, 2.Fac. Pharm., Meijo Univ., 3.Dept. Lab. Med., Sahlgrenska Acad., Univ. Gothenburg, Gothenburg, Sweden, 4.Lab. Clin. Chem., Sahlgrenska Univ. Hospit., Gothenburg, Sweden, 5.Dept. Orthopaedics Sports Med., Univ. Washington, Seattle, USA, 6.Bruker microCT, Kontich, Belgium)

キーテクノロジー：CRISPR/Cas9、HPLC、LC/MS

プロテオグリカン、エーラス・ダンロス症候群、B3GALT6、コンドロイチン硫酸、デルマタン硫酸