The Japanese Biochemical Society

[P-071] The stability of CMP-sialic acid synthetase was impaired by a point-mutation in the C-domain, which leads to lethality of medaka

Di Wu1,2,3, Akiko Fujita1, Hisashi Hashimoto4, Masahiko Hibi4, Yasuhiro Kamei5, Chihiro Sato1,2,3, Ken Kitajima1,2,3 (1.Biosci. Biotech. Center, 2.Grad. Sch. Bioagr. Sci., Nagoya Univ., 3.iGCORE, Nagoya Univ., 4.Grad. Sch. Sci., Nagoya Univ., 5.Nat. Inst. Basic Biol.)

キーテクノロジー:Gene editing

CMP-sialic acid synthetase、medaka、TILLING method 、gene knock-out

diwu@agr.nagoya-u.ac.jp

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