[P-154(3T13m-04)] ORP2 couples LDL-cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P₂ exchange

^○Kohta Takahashi^1,2,7, Kristiina Kanerva^1,2, Lauri Vanharanta^1,2, Leonardo Almeida-Souza^3,4,5, Daniel Lietha⁶, Vesa Olkkonen², Elina Ikonen^1,2 (1.Department of Anatomy and Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland, 2.Minerva Foundation Institute for Medical Research, Helsinki, Finland, 3.Helsinki Institute of Life Science, HiLIFE, University of Helsinki, Helsinki, Finland, 4.Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland, 5.Institute of Biotechnology, University of Helsinki, Helsinki, Finland, 6.Centro de Investigacions Margarita Salas (CIS), Spanish National Research Council (CSIC). Madrid, Spain, 7.Laboratory of Microbiology and Immunology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan)

キーテクノロジー：Degron system, D4H probe

コレステロール輸送、Focal adhesion kinase、OSBP-ralated protein、イノシトールリン脂質、リサイクリング