[P-207(1T15m-10)] Structural insights into biased agonism in sphingosine-1-phosphate receptors

^○Shintaro Maeda^1,2, Yuki Shiimura^3,4, Hidetsugu Asada⁴, Kunio Hirata⁵, Luo Fangjia⁵, Eriko Nango^5,6, Asuka Inoue⁷, Junken Aoki⁸, So Iwata^4,5, Masatoshi Hagiwara¹ (1.Department of Anatomy and Developmental Biology, Graduate school of Medicine, Kyoto University Japan, 2.Department of Drug Discovery Medicine, Graduate school of Medicine, Kyoto University Japan, 3.Institute of Life Science, Kurume University, Kurume, Japan, 4.Department of Cell Biology, Graduate school of Medicine, Kyoto University Japan, 5.RIKEN SPring-8, 6.Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai, Japan, 7.Laboratory of Molecular and Cellular Biolchemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan, 8.Department of Health Chemistry, Graduate School of Pharmaceutical Scienecs, The University of Tokyo)

キーテクノロジー：X線結晶構造解析

S1P、GPCR、構造生物学、S1PR3、シグナル伝達