The Japanese Biochemical Society

[P-266(2T15m-12)] Development of a selective degrader targeting hematopoietic prostaglandin D synthase

Norihito Shibata1, Hidetomo Yokoo2, Akinori Endo3, Takahito Ito4,5, Yuta Yanase4,5, Yuki Murakami4,5, Kiyonaga Fujii6, Kazunari Kondo1, Yasushi Saeki3, Mikihiko Naito7, Kosuke Aritake8, Yosuke Demizu4,5 (1.Division of Biochemistry, NIHS, 2.Medical Chemistry, Kyoto Prefectural University of Medicine, 3.Protein Metabolism Project, Tokyo Metropolitan Institute of Medical Science, 4.Division of Organic Chemistry, NIHS, 5.Graduate School of Medical Life Science, Yokohama City University, 6.Laboratory of Analytical Chemistry, Daiichi University of Pharmacy, 7.Laboratory of Targeted Protein Degradation, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 8.Laboratory of Chemical Pharmacology, Daiichi University of Pharmacy)

キーテクノロジー:プロテインノックダウン法

プロスタグランジンD合成酵素、筋ジストロフィー、プロテインノックダウン法

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