[P-295] Expression of trypanosomal acetate:succinate CoA transferase is sufficient to develop resistance to the ATP synthase inhibitor Bedaquiline in Mycobacterium smegmatis

^○M.G. Bundutidi^1,2,3, Ando Y.⁴, Matsuo Y.^5,6, Nakatani Y.^5,7, Kiel H.^7,8, Cook G. M.^7,8, Sakura T.^3,5, Hamano S.^1,2, Hirayama K.⁵, Kita K.^5,9,10, Inaoka D. K.^3,5,9 (1.Grad Sch Biomed Sci, Nagasaki Uni(NU), 2.Dept Parasitol, Inst Trop Med (NEKKEN), NU, 3.Dept Mole Infect Dyn, NEKKEN, NU, 4.Dept Infectious Dis Cont, Fac of Med, Oita Uni, 5.Sch Trop Med Glob Heal, NU, 6.Grad Sch Life Sci, Kumamoto Uni, 7.Dept Micro Immun, Sch Biomed Sci, Uni Otago, New Zealand, 8.Maurice Wilkins Cent Mol Biodis, Uni Auckland, New Zealand, 9.Dept Biomed Chem, Grad Sch Med, Uni Tokyo, 10.Dept Host-Def Biochem, NEKKEN, NU)

キーテクノロジー：Energy metabolism

ATP synthase、Bedaquiline、Mycobacterium 、SLPHOS