[P-303(1T13a-05)] Identification of 3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine derivatives as novel selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

^○Hartuti Endah Dwi^1,2,3, Takaya Sakura^4,5, Mohammed S. O. Tagod⁵, Eri Yoshida⁴, Xinying Wang^5,6, Kota Mochizuki⁷, Rajib Acharjee^1,2, Fuyuki Tokumasu⁸, Mihoko Mori⁹, Danang Waluyo³, Kazuro Shiomi⁹, Tomoyoshi Nozaki⁶, Shinjiro Hamano^1,2 (1.Program for Nurturing Global Leaders in Tropical and Emerging Communicable Disease, Nagasaki University, 2.Department of Parasitology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 3.Laboratory for Biotechnology, Agency for the Assessment and Application of Technology, Indonesia, 4.Department of Molecular Infection Dynamics, NEKKEN, Nagasaki University, 5.School of Tropical Medicine and Global Health, Nagasaki University, 6.Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7.Department of Immunogenetics, NEKKEN, Nagasaki University, 8.Department of Cellular Architecture Studies, NEKKEN, Nagasaki University, 9.Graduate School of Infection Control Sciences, Kitasato University, 10.Department of Host-Defense Biochemistry, NEKKEN, Nagasaki University)

キーテクノロジー：PfDHODH inhibitors screening

Plasmodium falciparum、dihydroorotate dehydrogenase、inhibitor screening、antimalarial drug