[P-740] PRC2 insufficiency induces p53-dependent dyserythropoiesis in myelodysplastic syndrome through Cdkn2a de-repression

^○Kazumasa Aoyama^1,2, Daisuke Shinoda^1,2, Emi Suzuki², Yaeko Nakajima-Takagi^1,2, Motohiko Oshima^1,2, Shuhei Koide^1,2, Ola Rizq^1,2, Shiro Tara², Goro Sashida^2,3, Atsushi Iwama^1,2 (1.Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, 2.Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, 3.International Research Center for Medical Sciences, Kumamoto University)

キーテクノロジー：NGS

PRC2、H3K27me3、epigenetics、dyserythropoiesis、MDS