The Japanese Biochemical Society

[Introduction] Introduction

Shigeki Iwase (The University of Michigan Medical School)

The 94th Annual Meeting of JBS |Thu. Nov 4, 2021 9:00 AM - 9:03 AM

[2S10m-04] The maturation of the mammalian brain occurs after birth, and this stage of neuronal development is frequently impaired in neurological disorders, such as autism and schizophrenia. However, the mechanisms that regulate postnatal brain maturation are poorly defined. By purifying neuronal subpopulations across brain development in mice, we identify a postnatal switch in the transcriptional regulatory circuits that operates in the maturing mammalian brain. We show that this developmental transition includes the formation of hundreds of cell-type-specific neuronal enhancers that appear to be modulated by neuronal activity. Once selected, these enhancers are active throughout adulthood, suggesting that their formation in early life shapes neuronal identity and regulates mature brain function.

Stroud Hume (University of Texas Southwestern Medical Center)

The 94th Annual Meeting of JBS |Thu. Nov 4, 2021 10:30 AM - 10:58 AM