[1P-147] Gain of resistance to bedaquiline by expression of trypanosomal acetate:succinate CoA transferase in Mycobacterium smegmatis

^〇Bundutidi G. M.^1,2,3, Ando Y.⁴, Matsuo Y.^5,6, Hayashishita M.⁵, Mochizuki K.¹, Cook G.M.⁷, Sekijima M.⁸, Sakura T.^3,5, Hamano S.^1,2, Hirayama K.⁵, Kita K.^5,9, Inaoka D.K.^3,5,9 (1.Grad Sch of Biomed Sci, Nagasaki Univ, 2.Dept of Parasitol,Nagasaki Univ, 3.Dept of Mol Infect Dynamics, Nagasaki Univ, 4.Dept of Infect Dis Contl, Oita Univ, 5.Sch of Trop Med and Glob Health, Nagasaki Univ, 6.Grad Sch of Life Sci, Kumamoto Univ, 7.Grad Sch of Life Sci, Kumamoto Univ, 8.Dept of Microbiol and Immunol, Univ of Otago, 9.Dept of Adv Comput Drug Discov Unit,Tokyo Inst of Tech, 10.Dept of Biomed Chem, Univ of Tokyo)

キーテクノロジー：Energy metabolism

ATP synthase、Bedaquiline resistance