[1P-357（3T10a-01）] Species-specific aggregation of canine SOD1 caused by degenerative myelopathy linked-E40K mutation is derived from endogenous vulnerability in the hydrophobic core of protein

^〇Kei Hashimoto¹, Seiji Watanabe¹, Hiroaki Kamishina^2,3, Msato Akutsu⁴, Yoshiaki Furukawa⁴, Koji Yamanaka¹ (1.Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya university, 2.Kyoto Animal Referral Medical Center, 3.Life Science Research Center, Gifu university, 4.Department of Chemistry, Keio university)

キーテクノロジー：crystal structure analysis

canine degenerative myelopathy、amyotrophic lateral sclerosis、SOD1