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[1T04a-03(2P-059)] Disruption of NPC1L1 impairs transcellular lipid trafficking and induces large lipid droplet formation in intestinal absorptive epithelial cells

Takanari Nakano1, Rina Ito1, Norihiro Kotani1,5, Liqing Yu2, Yiannis A. Ioannou3, Masataka Hirasaki4, Takayuki Murakoshi1 (1.Dept. Biochem., Saitama Med. Univ., 2.Dept. Med., Div. Endocrinol., Diabetes & Nutrition, Univ. Maryland, School of Medicine, 3.Dept. Genetics and Genomic Sci., Icahn School of Medicine at Mount Sinai, 4.Dept. Clin. Cancer Genomics, Int. Med. Center, Saitama Med. Univ., 5.Medical Research Center, Saitama Med. Univ.)

キーテクノロジー:Luminal perfusion in mice

コレステロール、カイロミクロン、腸上皮細胞、Niemann-Pick C1-like 1

tnakano@saitama-med.ac.jp

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