1:20 PM - 1:30 PM

[1T12a-01（2P-212）] CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP

^〇Masashi Maekawa^1,2,3, Kanako Nishiyama^3,4, Tomoya Nakagita⁵, Jun Nakayama⁶, Takeshi Kiyoi⁷, Mami Chosei², Akari Murakami⁴, Yoshiaki Kamei⁴, Hiroyuki Takeda⁵, Yasutsugu Takada⁴, Shigeki Higashiyama^2,3,8 (1.Division of Physiological Chemistry and Metabolism, Graduate School of Pharmaceutical Sciences, Keio University, 2.Division of Cell Growth and Tumor Regulation, Proteo-Science Center, Ehime University, 3.Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, 4.Department of Hepato-Biliary-Pancreatic Surgery and Breast Surgery, Ehime University Graduate School of Medicine, 5.Division of Proteo-Drug-Discovery Sciences, Proteo-Science Center, Ehime University, 6.Division of Cellular Signaling, National Cancer Center Research Institute, 7.Division of Analytical Bio-medicine, Advanced Research Support Center, Ehime University, 8.Department of Tumor Growth Regulation, Osaka International Cancer Institute)

キーテクノロジー：プロテインアレイ

EGFRホスファターゼ、HER2陽性乳癌細胞、タンパク質間相互作用、CUL3型ユビキチンリガーゼ