[2P-087] The inhibition of LUBAC mitigates amyotrophic lateral sclerosis-associated TDP-43 aggregation

^〇Qiang Zhang¹, Seigo Terawaki^1,2, Daisuke Oikawa ^1,3, Yoshinori Okina³, Yoshinosuke Usuki ⁴, Fuminori Tokunaga^1,3 (1.Department of Pathobiochemistry, Graduate School of Medicine, Osaka City University, Osaka, Japan, 2.Department of Molecular and Genetic Medicine, Kawasaki Medical School, Okayama, Japan, 3.Department of Medical Biochemistry, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan, 4.Department of Chemistry, Graduate School of Science, Osaka Metropolitan University, Osaka, Japan)

キーテクノロジー：Immunofluorescent staining

ALS、 TDP-43、protein aggregation、neuroinflammation、linear ubiquitination