The Japanese Biochemical Society

[2P-212(1T12a-01)] CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP

Masashi Maekawa1,2,3, Kanako Nishiyama3,4, Tomoya Nakagita5, Jun Nakayama6, Takeshi Kiyoi7, Mami Chosei2, Akari Murakami4, Yoshiaki Kamei4, Hiroyuki Takeda5, Yasutsugu Takada4, Shigeki Higashiyama2,3,8 (1.Division of Physiological Chemistry and Metabolism, Graduate School of Pharmaceutical Sciences, Keio University, 2.Division of Cell Growth and Tumor Regulation, Proteo-Science Center, Ehime University, 3.Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, 4.Department of Hepato-Biliary-Pancreatic Surgery and Breast Surgery, Ehime University Graduate School of Medicine, 5.Division of Proteo-Drug-Discovery Sciences, Proteo-Science Center, Ehime University, 6.Division of Cellular Signaling, National Cancer Center Research Institute, 7.Division of Analytical Bio-medicine, Advanced Research Support Center, Ehime University, 8.Department of Tumor Growth Regulation, Osaka International Cancer Institute)

キーテクノロジー:プロテインアレイ

EGFRホスファターゼ、HER2陽性乳癌細胞、タンパク質間相互作用、CUL3型ユビキチンリガーゼ

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