The Japanese Biochemical Society

[2P-355] Generation of antagonistic monoclonal antibodies against the neoepitope of active mouse interleukin (IL)-18 and development of bioassay system for their evaluation

Yuko Nariai1, Yuki Uchida1,2, Eiji Obayashi1,3, Yoshitsugu Tajima2, Tomohiro Koga4,5, Atsushi Kawakami4, Takeshi Urano1,3,6, Hiroki Kamino1,3 (1.Department of Biochemistry, Shimane University School of medicine, 2.Department of Digestive and General surgery, Shimane University School of medicine, 3.mAb Protein Co.Ltd., 4.Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical sciences, 5.Center for Bioinformatics and molecular medicine, Nagasaki University Graduate School of Biomedical sciences, 6.Vaccine and Therapeutic Antibodies for Emerging Infectious Diseases, Shimane University School of medicine)

キーテクノロジー:マウスモノクローナル抗体作製

マウスIL-18 、機能阻害モノクローナル抗体

nariai@med.shimane-u.ac.jp

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