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[2T03a-02(2P-050)] Biosynthetic crossover of 5-lipoxygenase and cyclooxygenase-2 yields 5-hydroxy-PGE2 and 5-hydroxy-PGD2

Fumie Nakashima1, Paula Luis2, SaiHan Presley2, Takahiro Shibata1, Ambra Pozzi4, Claus Schneider2,3 (1.Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, 2.Division of Clinical Pharmacology and Department of Pharmacology, Vanderbilt University, 3.Vanderbilt Institute of Chemical Biology, Vanderbilt University, 4.Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine)

キーテクノロジー:質量分析

cyclooxygenase、lipoxygenase、アラキドン酸、エイコサノイド、プロスタグランジン

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