The Japanese Biochemical Society

[3P-021(3T03a-09)] CDP-ribitol prodrug treatment ameliorates ISPD-deficient muscular dystrophy mouse model

Hideki Tokuoka1, Rieko Imae2, Hitomi Nakashima1, Hiroshi Manya2, Chiaki Masuda3, Shunsuke Hoshino2, Kazuhiro Kobayashi1, Dirk J. Lefeber4, Riki Matsumoto1, Takashi Okada5, Tamao Endo2, Motoi Kanagawa1,6, Tatsushi Toda7 (1.Division of Molecular Brain Science and Neurology, Kobe University Graduate School of Medicine, 2.Molecular Glycobiology, Research Team for Mechanism of Aging, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 3.Department of Biochemistry and Molecular Biology, Nippon Medical School, 4.Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, 5.Division of Molecular and Medical Genetics, Center for Gene and Cell Therapy, The Institute of Medical Science, The University of Tokyo, 6.Department of Cell Biology and Molecular Medicine, Ehime University Graduate School of Medicine, 7.Department of Neurology, Graduate School of Medicine, The University of Tokyo)

キーテクノロジー:ドラッグデリバリーシステム

CDP-リビトール、ジストログリカン、プロドラッグ、筋ジストロフィー

htokuoka@med.kobe-u.ac.jp

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