[1P-286] A novel Photochromic inhibitor SPSAB showed inhibition of Eg5 ATPase cycle in ADP state

^〇Md Alrazi Islam ¹, Shinsaku Maruta¹ (Soka University, Hachioji, Japan)

The 95th Annual Meeting of the Japanese Biochemical Society

[1P-287（1T15a-04）] Functional analysis of SHP2 in scirrhous gastric carcinoma with gene amplification of receptor tyrosine kinases

^〇Hideki Yamaguchi¹, Yuko Nagamura¹, Makoto Miyazaki¹ (Department of Cancer Cell Research, Sasaki Institute, Sasaki Foundation)

The 95th Annual Meeting of the Japanese Biochemical Society

[1P-288（2T14a-01）] SMG6 Regulates DNA Damage and Cell Survival in Hippo Pathway Kinase LATS2-Inactivated Malignant Mesothelioma

^〇Koya Suzuki^1,2,3, Ryota Yamagishi⁴, Satomi Mukai⁵, Tomohiro Akashi⁶, Ichiro Takeuchi⁷, Kenji Kadomatsu⁸, Tohru Maeda⁹, Hiroshi Murakami¹⁰, Takashi Miida², Yoshitaka Sekido⁵, Yuko Murakami-Tonami^1,2 (1.Mol. Cancer Genet. Lab., Tokyo Univ. Tech. Grad Sch. Bionics, 2.Dept. Clin. Lab. Med., Juntendo Univ. Grad. Sch. Med., 3.Adv. Comp. Res. Org., Teikyo Univ., 4.Dept. Pathophys., Osaka Met. Univ. Grad. Sch. Med, 5.Div. Cancer. Biol., Aichi Cancer Ctr. Res. Inst., 6.Dept. Integrative Cellular Inform., Nagoya Univ. Grad. Sch. Med., 7.Mech. Sys. Eng., Nagoya Univ. Grad. Sch. Eng., 8.Dept. Biochem., Nagoya Univ. Grad. Sch. Med., 9.Col. Pharm., Kinjo Gakuin Univ., 10.Dept. Biol. Sci., Fac. Sci. Eng., Chuo Univ.)

The 95th Annual Meeting of the Japanese Biochemical Society

[1P-289] Search for candidate compounds that suppress cell proliferation specific to malignant mesothelioma causative gene mutation

^〇Masaki Tange¹, Koya Suzuki^1,2,3, Toshihiro Takeuchi¹, Yusuke Nishiya¹, Takashi Miida², Hiroshi Murakami⁴, Yoshitaka Sekido⁵, Ichiro Hayakawa⁶, Ayato Sato⁷, Yuko Murakami-Tonami^1,2 (1.Mol. Cancer Genet. Lab., Tokyo Univ. Tech. Grad Sch. Bionics, 2.Dept. Clin. Lab. Med., Juntendo Univ. Grad. Sch. Med., 3.Adv. Comp. Res. Org., Teikyo Univ., 4.Dept. Biol. Sci., Fac. Sci. Eng., Chuo Univ., 5.Div. Cancer. Biol., Aichi Cancer Ctr. Res. Inst., 6.Nihon Univ., Grad. Sch. Integr. Basic Sci., 7.ITbM, Nagoya Univ.)

The 95th Annual Meeting of the Japanese Biochemical Society

[1P-290] Role of deregulated protein neddylation in myeloid transformation

^〇Takeshi Ueda¹, Suman Dash¹, Masahiko Honda¹, Akiyoshi Komuro¹, Hitoshi Okada¹ (Department of Biochemistry, Kindai University Faculty of Medicine, Japan)

The 95th Annual Meeting of the Japanese Biochemical Society

[1P-291] Effect of childhood ionizing radiation exposure on NASH-like pathological disorder induction and hepatocellular carcinoma development in mouse model

^〇Yi Shang¹, Takamitsu Morioka¹, Shizuko Kakinuma¹ (Department of Radiation Effects Research, National Institute of Radiological Sciences, National Institutes for Quantum Science and Technology)

The 95th Annual Meeting of the Japanese Biochemical Society

[1P-292] Development and evaluation of a novel micelle-based DDS tool for cancer therapy

^〇Koji Takezawa¹, Atsushi Tabata^1,2, Toshifumi Tomoyasu^1,2, Hideaki Nagamune^1,2 (1.Grad. Sch. Sci. & Tech. for Innov., Biosci., Tokushima Univ., 2.Div. Biosci. & Bioindust., Grad. Sch. Tech., Indust. & Social Sci., Tokushima Univ.)

The 95th Annual Meeting of the Japanese Biochemical Society

[1P-293（1T15a-05）] Inactivation of axon guidance molecule netrin-1 in human colorectal cancer by an epigenetic mechanism

^〇Hironao Nakayama¹, Masako Nakahara¹, Chiaki Kusumoto¹ (Department of Medical Science and Technology, Hiroshima International University)

The 95th Annual Meeting of the Japanese Biochemical Society

[3P-392] Comparison of the effects between sorafenib and lenvatinib on advanced liver cancer associated-cell invasion and angiogenesis

^〇Wang Ting¹, Toshimi Chiba¹ (Division of Internal Medicine, Department of Oral Medicine, Iwate Medical University)

The 95th Annual Meeting of the Japanese Biochemical Society

[1P-295（1T16a-05）] Involvement of mitochondrial reactive oxygen species in anticancer activity of γ-glutamylcyclotransferase inhibitor in MCF7 breast cancer cells

^〇Hiromi Ii¹, Kozue Nose¹, Chiami Moyama¹, Shota Ando¹, Keiko Taniguchi², Taku Yoshiya^3,4, Yukie Nohara³, Susumu Kageyama⁵, Susumu Nakata¹ (1. Dept. of Clinical Oncology, Kyoto Pharmaceutical University, 2.Dept. of Drug Discovery Medicine, Kyoto Prefectural University of Medicine, 3.Peptide Institute, Inc., 4.Institute for Protein Reserch, Osaka University, 5.Dept. of Urology, Shiga University of Medical Science)

The 95th Annual Meeting of the Japanese Biochemical Society