[1P-098] In Silico and In Cell Hybrid Selection of Nonrapalog Ligands to Allosterically Inhibit the Kinase Activity of mTORC1

Raef Shams^1,2, Akihiro Matsukawa³, Yukari Ochi³, Yoshihiro Ito^1,4, ^〇Hideyuki Miyatake^2,4 (1.Emergent Bioengineering Materials Research Team, RIKEN Center for Emergent Matter Science, RIKEN, Wako, Saitama 351-0198, Japan, 2.Department of Life Science, Graduate School of Science and Engineering, Saitama University, Saitama City, Saitama 338-8570, Japan, 3.Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 700-8558 Okayama, Japan, 4.RIKEN Cluster for Pioneering Research, RIKEN, Wako, Saitama 351-0198, Japan)

キーテクノロジー：in silico選択と細胞内FRET

mTORC1、アロステリック阻害、非ラパログ、in silico選択、in cell選択