[1P-148] Mechanistic aspects of PROTAC-mediated ubiquitination and p97 requirement

^〇Kouta Nakadai^1,2,3, Akinori Endo³, Takuya Tomita³, Norihito Shibata⁴, Yousuke Demizu^3,5,6, Kousuke Aritake⁷, Yasushi Saeki² (1.Graduate School of Frontier Sciences, The University of Tokyo, 2.Division of Protein Metabolism, Institute of Medical Science, The University of Tokyo, 3.Laboratory of Protein Metabolism,Tokyo Metropolitan Institute of Medical Science, 4.Division of Biochemistry, National Institute of Health Sciences, 5.Division of Organic Chemistry, National Institute of Health Sciences, 6.Graduate School of Medical Life Science, Yokohama City University, 7.Laboratory of Chemical Pharmacology, Daiichi University of Pharmacy)

キーテクノロジー：HiBiTタグによる高感度検出

ユビキチン、プロテアソーム、PROTAC