[1P-236] Acquisition of bedaquiline tolerance in Mycobacterium smegmatis by overexpression of trypanosomal acetate:succinate CoA transferase

^〇Gloria Mavinga Bundutidi^1,2,3, Yuri Ando⁴, Yuichi Matsuo⁵, Hayashishita Mizuki⁶, Mochizuki Kota^1,2,6, Cook Gregory Murray⁷, Masakazu Sekijima⁸, Takaya Sakura^3,6, Hamano Shinjiro^1,2, Hirayama Kenji⁶, Kiyoshi Kita^6,9,10, Inaoka Daniel Ken^3,6,9 (1.Grad Sch of Biomed Sci, Nagasaki Univ, 2.Dept of Parasitol, Inst of Trop Med (NEKKEN), Nagasaki Univ, 3.Dept of Mol Infect Dynamics, NEKKEN, Nagasaki Univ, 4.Dept of Infect Dis Cont, Oita Univ, 5.Grad Sch of Life Sci, Kumamoto Univ, 6.Sch of Trop Med and Glob Health, Nagasaki Univ, 7.Dept of Microbiol and Immunol, Univ of Otago, 8.Dept of Adv Comp Drug Disc Unit, Tokyo Inst of Tech, 9.Dept of Biomed Chem, The Univ of Tokyo)

キーテクノロジー：Energy metabolism

Bedaquiline、mechanism of action、metabolic engineering、ATP level、ASCT/SCS cycle