The Japanese Biochemical Society

[1P-588] A versatile Plasmodium falciparum reporter line expressing NanoLuc enables highly sensitive multi-stage drug assays

Yukiko Miyazaki1, Martijn W Vos2, Fiona J.A. Geurten3, Pierre Bigeard4, Hans Kroeze3, Shohei Yoshioka5, Mitsuhiro Arisawa5, Daniel K. Inaoka1, Valerie Soulard4, Koen J. Dechering2, Blandine Franke-Fayard3, Shinya Miyazaki6 (1.Department of Molecular Infection Dynamics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Japan, 2.Department of Parasitology, Leiden University Medical Center, The Netherlands, 3.TropIQ Health Sciences, The Netherlands, 4.Sorbonne Universite, Inserm, CNRS, Centre d'Immunologie et des Maladies Infectieuses, CIMI-Paris, France, 5.Graduate School of Pharmaceutical Sciences, Osaka University, Japan., 6.Department of Cellular Architecture Studies, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Japan.)

キーテクノロジー:遺伝子改変

熱帯熱マラリア原虫、CRISPR/Cas9、NanoLuc、創薬

y.miyazaki@nagasaki-u.ac.jp

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