Ago2 and a miRNA reduce DNA topoisomerase 1 (Top1) for enhancing DNA cleavage in antibody diversification by activation-induced cytidine deaminase (AID)

Maki Kobayashi

[1P-618(1T17-09)] Ago2 and a miRNA reduce DNA topoisomerase 1 (Top1) for enhancing DNA cleavage in antibody diversification by activation-induced cytidine deaminase (AID)

^〇Maki Kobayashi¹, Hiroyuki Wakaguri², Masakazu Shimizu², Koichiro Higasa², Fumihiko Matsuda², Tasuku Honjo¹ (1.Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Kyoto University Graduate School of Medicine, 2.Center for Genomic Medicine, Kyoto University Graduate School of Medicine)

キーテクノロジー：遺伝子ノックアウト

免疫記憶、抗体遺伝子組換え、トポイソメラーゼ１、AID

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The 96th Annual Meeting of the Japanese Biochemical Society

[1P-618(1T17-09)] Ago2 and a miRNA reduce DNA topoisomerase 1 (Top1) for enhancing DNA cleavage in antibody diversification by activation-induced cytidine deaminase (AID)

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