The Japanese Biochemical Society

[1P-652] Prostate cancer acquires castration resistance via 3-O-sulfated heparan sulfate.

Hayato Ota1, Hirokazu Sato1, Shuji Mizumoto2, Ken Wakai3, Kei Yoneda3, Kazuo Yamamoto3, Hayao Nakanishi4, Jun-Ichiro Ikeda3, Shinichi Sakamoto3, Tomohiko Ichikawa3, Shuhei Yamada2, Satoru Takahashi5, Yuzuru Ikehara3, Shoko Nishihara1,6 (1Graduate School of Engineering, Soka University, 2Faculty of Pharmacy, Meijo University, 3Graduate School of Medicine, Chiba University, 4Aichi Cancer Center Aichi Hospital, 5Graduate School of Medical Sciences, Nagoya City University, 6Glycan & Life System Integration Center (GaLSIC), Soka University)

キーテクノロジー:ヘパラン硫酸の発現制御

去勢抵抗性前立腺がん、3-O-硫酸化へパラン硫酸、分子標的治療薬

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