[2P-140] Nuclear export suppression of p62/Sqstm1 causes severe kidney failure in mice

^〇BAOSHUO NING¹, Kawanishi Kunio², Kang Dedong³, Mohammed Elsayed S. I. ¹, Tatsuno Rinna¹, Fuseya Sayaka¹, Usui Toshiaki⁴, Morito Naoki⁴, Yanagawa Toru ⁵, Mizuno Seiya ⁶, Takahashi Satoru ¹, Warabi Eiji ¹ (1.Department of Anatomy and Embryology, Institute of Medicine, University of Tsukuba, Ibaraki, Japan, 2.Experimental Pathology, Institute of Medicine, University of Tsukuba, Ibaraki, Japan, 3.Department of Anatomy, Showa University School of Medicine, Shinagawa, Tokyo, Japan, 4.Department of Nephrology, Institute of Medicine, University of Tsukuba, Ibaraki, Japan, 5.Department of Oral and Maxillofacial Surgery, Institute of Medicine, University of Tsukuba, Ibaraki, Japan, 6.Laboratory Animal Resource Center, Transborder Medical Research Center, Institute of Medicine, University of Tsukuba, Ibaraki, Japan)

キーテクノロジー：CRISPR/Cas9

autophagy、p62、podocyte damage、kidney failure