[2P-142] Thalidomide derivatives and proteolysis-targeting chimeras for controlling neosubstrate degradation

^〇Satoshi Yamanaka^1,2, Hirotake Furihata^2,3, Mai Usui⁴, Koya Nagaoka², Yuki Shoya², Kohei Nishino⁵, Hidetaka Kosako⁵, Masaru Tanokura³, Takuya Miyakawa^3,6, Norio Shibata⁴, Tatsuya Sawasaki² (1.Division of Proteo-Interactome, Proteo-Science Center, Ehime University, 2.Division of Cell-Free Sciences, Proteo-Science Center, Ehime University, 3.Graduate School of Agricultural and Life Sciences, The University of Tokyo, 4.Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Nagoya, 5.Division of Cell Signaling, Fujii Memorial Institute of Medical Sciences, Tokushima University, 6.Graduate School of Biostudies, Kyoto University)

キーテクノロジー：標的タンパク質分解

タンパク質分解誘導剤、E3 ユビキチンリガーゼ、タンパク質分解