[2P-187] Mechanism of action of an antimalarial compound isolated from Nagasaki University's marine microbial extracts: targeting mitochondrial electron transport chain

Normalita Eka Pravitasari^1,2, ^〇Takaya Sakura^1,3, Kibet Ng'etich Japheth^4,5, Jun Takouda⁶, Shusaku Mizukami⁷, Kenji Hirayama^1,8, Kohsuke Takeda⁶, Yoshimasa Tanaka⁹, Kiyoshi Kita^1,10,11, Daniel Ken Inaoka^1,3,11 (1.School of Tropical Medicine and Global Health, Nagasaki University, 2.Struct Mol and Regener Med, Eijkman Res Center for Mol Biol Nat Res and Innov, 3.Department of Molecular Infection Dynamics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 4.Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, 5.Center for Trad Med and Drug Res, Kenya Med Res Inst, 6.Department of Cell Regulation, Graduate School of Biomedical Sciences, Nagasaki University, 7.Department of Immune Regulation, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 8.Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 9.Center for Medical Innovation, Nagasaki University, 10.Department of Host-Defense Biochemistry, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 11.Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo)

キーテクノロジー：天然物創薬

マラリア、創薬、天然物、呼吸鎖