The Japanese Biochemical Society

[2P-640] Stabilization of the CH2 domain, the least stable domain in antibody therapeutics, to prevent aggregation

Kosuke Oyama1, Jose Manuel Martinez Caaveiro2, Naoya Matsunaga3, Kengo Hamamura3, Yuya Yoshida3, Shigehiro Ohdo1, Tadashi Ueda1 (1.Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyushu University, 2.Department of Global Healthcare, Faculty of Pharmaceutical Sciences, Kyushu University, 3.Department of Clinical Pharmacokinetics, Faculty of Pharmaceutical Sciences, Kyushu University)

キーテクノロジー:タンパク質の物性評価

CH2ドメイン、凝集、蛋白質工学、抗体

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