The aim of this study was to identify the trends and update the knowledge base regarding recent research on the use of the Omaha System (OS) in research, practice, and education through a scoping review. For analysis, we used 71 PubMed articles published between 2012 and 2019 that employed the OS. The number of research articles using the OS demonstrated a gradually increasing trend, compared with the that before 2011. The focus of these articles included the exchangeability with other terminologies, the feasibility of encoding evidence-based clinical guidelines, and the usage on flamework for interventional study and nursing education.