Despite the development of recombinant growth hormone (GH) treatment and the benefits in long-term clinical health outcomes, evidence has shown that many children with GH-treated growth disorders still fail to achieve their target adult height. Suboptimal outcomes have been largely attributed to treatment non-adherence. Adherence is routinely assessed at clinic visits; however, this provides little information about what is happening between visits, as reported data is frequently over- or underestimated by patients/caregivers. Connected eHealth devices, with automatic recording and transmission of adherence data, provide more accurate insights into individual patients’ management. Our ongoing activities incorporate several patient empowerment tools to connect clinician/nurse and patient/ caregiver to provide a better system of care for GH therapy. These include mobile-based augmented reality (AR) combined with interactive avatars for patient education, and patient support programs with integrated behavior change techniques.