Japan Association for Medical Informatics

[2-G-2-06] Prevalence and Mortality Trends of Interstitial Lung Disease and Pulmonary Sarcoidosis in High Income Asia Pacific Region from 1990 to 2019

*Jennifer Saulam1,2, Syed Mahfuz Al Hasan3, Fumiaki Mikami1, Masatoshi Tanigawa3, Hideto Yokoi1,3 (1. Department of Medical Informatics, Kagawa University Hospital, Kagawa, Japan, 2. Department of Food Processing and Nutrition, Karnataka State Akkamahadevi Women’s University, Vijayapura, India, 3. Clinical Research Support Centre, Kagawa University Hospital, Kagawa, Japan)

Interstitial Lung Disease, High Income Asia Pacific, Joinpoint Regression Analysis

Aim: The study aimed to analyze temporal changes and comparison in age-standardized rates of prevalence and mortality of interstitial lung disease (ILD) and pulmonary sarcoidosis among males and females in Japan and other three High-Income Asia Pacific Region (Brunei, South Korea, and Singapore) from 1990 to 2019. Methods: We conducted joinpoint regression analysis using Global Burden of Disease database. We calculated average annual percentage change (AAPC) using weighted average of annual percent changes for each segment of prevalence and mortality trends of ILD and pulmonary sarcoidosis. Results: Prevalence of ILD and pulmonary sarcoidosis in High-income Asia Pacific region increased significantly by 0.3% annually from 1990 to 2019. Age-standardized mortality rate of ILD and pulmonary sarcoidosis increased two times higher among males (AAPC=1.2) compared to females (AAPC=0.6) from 1990 to 2019. Increase in prevalence and mortality was observed highest in South Korea among both males and females. Prevalence increased significantly by an average of 2.7% (2.6% to 2.7%) and 1.9 % (1.9% to 2.0%) annually among males and females in South Korea respectively. Furthermore, mortality rate also increased significantly by 1.8% (1.6% to 2.1%) in males and 1.5% (1.2% to 1.7%) in females annually. Whereas, age-standardized rate of mortality (AAPC=-0.9) and prevalence (AAPC=-0.6) decreased significantly among both males and females in Brunei. In Japan, prevalence rate among males significantly increased by 0.3% annually but a non-significant increase among females by 0.1%. Mortality rate was found to be significantly increased in Japan both males and females by 1.2% and 0.6%, respectively. Conclusion: High-Income Asia Pacific Region showed significant increase in the rate of mortality and prevalence of ILD and pulmonary sarcoidosis from 1990 to 2019.