A trial for the creation of real-world evidence, commonly known as “Rinchu-Net,” was launched in mid 2018 on 12 clinical study core hospitals with the support of the Japan Agency for Medical Research and Development (AMED). After four years, two hospitals were added to core hospitals. As the undertaken program, involving 14 hospitals, is two and a half years away from its completion, a picture of an exit strategy at the end of the fiscal year 2024 should be drawn by backcasting based on future predictions made also according to the experiences during the COVID-19 pandemic. Originally, “Rinchu-Net” not only aimed at the development of clinical study core hospitals but also at the creation of a starting point for nationwide infrastructure aimed at real-world data utilization. The project demands a philosophy and a concrete plan for the creation of the said infrastructure as the exit strategy. In this workshop, a hospital representative, an AMED representative, and the Ministry of Health, Labor, and Welfare will present lectures and discussions on the concerned theme. The representative director and the chairman of the scientific committee of the Japan Association for Medical Informatics will join the discussion to outline future expectations and the exit strategy of “Rinchu-Net” from an academic perspective.