[1P-0413] Nitric oxide induces neuronal cell death through S-nitrosylation of the type 1 ryanodine receptor

〇Yoshinori Mikami^1,2, Kazunori Kanemaru², Yohei Okubo², Takuya Nakaune², Junji Suzuki², Sho Kakizawa³, Takashi Murayama⁴, Kazuki Shibata⁵, Ryuta Koyama⁵, Akihiro Ito⁶, Toshiko Yamazawa⁷, Masanori Ito¹, Taichiro Tomida¹, Shingo Murakami¹, Satomi Adachi-Akahane¹, Takashi Sakurai⁴, Yuji Ikegaya⁵, Nobuhito Saito⁶, Masamitsu Iino^2,8 (1.Dept. of Physiol., Sch. of Med., Fac. of Med., Toho Univ., 2.Dept. of Pharmacol., Grad. Sch. of Med., Univ. of Tokyo, 3.Dept. of Biol. Chem., Grad. Sch. of Pharmaceu. Sci., Kyoto Univ., 4.Dept. of Pharmacol., Grad. Sch. of Med., Juntendo Univ., 5.Lab. of Chem. Pharmacol., Grad. Sch. of Pharmaceut. Sci., Univ. of Tokyo, 6.Dept. of Neurosurg., Grad. Sch. of Med., Univ. of Tokyo, 7.Dept. of Mol. Physiol., Jikei Univ. Sch. of Med., 8.Dept. of Cell. Mol. Pharmacol., Nihon Univ. Sch. of Med.)

Nitric oxide, Ryanodine receptor, Calcium, S-nitrosylation, Neuronal cell death