[1P-0529] Paternal aging-induced differential DNA methylation in sperm affects gene expression and behavior in offspring: a transgenerational epigenetical model for neurodevelopmental disorders

〇Ryuichi Kimura¹, Kaichi Yoshizaki¹, Tasuku Koike², Hisato Kobayashi³, Kohei Koike¹, Takako Kikkawa¹, Hitoshi Inada¹, Takuya Imamura⁴, Kinichi Nakashima⁴, Yasuhisa Matsui⁵, Tomohiro Kono², Noriko Osumi¹ (1.Dept. of Dev. Neurosci., Tohoku Univ. Grad. Sch. of Med., 2.Dept. of Biosci., Tokyo Univ. of Agri., 3.NODAI Genome Research Center, Tokyo Univ. of Agri., 4.Dept. of Stem Cell Biology and Medicine, Grad. Sch. of Med. Sci., Kyushu Univ., 5.Cell Resource Center for Biomedical Research, Inst. of Development, Aging and Cancer)

advanced paternal age, DNA methylation, autism, schizophrenia, sperm