[1P-0650] Effects of mutant IDH producing D-2-HG on the differentiation property and transformation of mesenchymal stem cells.

〇Takeshi Kamakura^1,2, Yonghui Jin^1,3, Makoto Watanabe^2,4, Kazuhito Matsunaga^2,5, Sakura Tamaki^1,2, Takeshi Okamoto⁶, Hiroyuki Yoshitomi^1,2, Junya Toguchida^1,2,6 (1.Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan, 2.Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan, 3.Institute for Advancement of Clinical and Translational Science, Kyoto University Hospital, Kyoto, Japan, 4.Life Science Research Center, Shimadzu Coopration, Kyoto, Japan, 5.Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi, Japan., 6.Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan)

IDH mutation, Oncometabolite, Cartilage tumor, MSC, iPSC