[1P-0691] p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming.

〇Tetsuya Saito¹, Yoshinobu Ichimura¹, Keiko Taguchi², Takafumi Suzuki², Tsunehiro Mizushima³, Tsutomu Fujimura⁴, Takashi Ueno⁵, Tomoyuki Ohe⁶, Tadahiko Mashino⁶, Toshifumi Wakai⁷, Takayoshi Okabe⁸, Tetsuo Nagano⁸, Hozumi Motohashi⁹, Satoshi Waguri¹⁰, Tomoyoshi Soga⁶, Masayuki Yamamoto², Keiji Tanaka¹¹, Masaaki Komatsu¹ (1.Dept. of Biochem. Niigata Univ. Grad. Sch. of Med. and Dent. Sci., 2.Dept. of Med. Biochem., Tohoku Univ. Grad. Sch. of Med., 3.Univ. of Hyogo, 4.Tohoku Med. and Pharm. Univ., 5.Juntendo Univ., 6.Keio Univ., 7.Div. of Digest. and Gener. Surg. Niigata Univ. Grad. Sch. of Med. and Dent. Sci., 8.Drag Discov. Init., The Univ. of Tokyo, 9.Aging and Cancer, Tohoku Univ., 10.Fukushima Med. Univ. Sch. of Med., 11.Lab. of Protein Metab. , Tokyo Metr. Inst. of Med. Sci.)

肝細胞がん細胞, p62-Keap1-Nrf2経路, 代謝リプログラミング