[1P-0698(1PS8-7)] Glutamine synthetase function overrides a novel metabolic checkpoint of cell growth mediated by Hypoxia-Inducible Factors

〇Shojiro Kitajima¹, Kian Leong Lee¹, Ruby Yun-Ju Huang¹, Henry Yang¹, Marito Araki², Hiroyuki Kato¹, Lorenz Poellinger^1,3 (1.Cancer Sci. Inst. of Singapore, Nat. Univ. of Singapore, 2.Dept. of Transfusion Med. and Stem Cell Regulation, Juntendo Univ. Grad. Sch. of Med., 3.Karolinska Institutet, Department of Cell and Molecular Biology)

Metabolic stress response, Hypoxia, Cancer metabolism, Glutamine synthetase