[1P-0721(2AS14-5)] Aggregation propensity and structural change of TDP-43 carrying ALS-linked mutation in intrinsically disordered region in live cells

〇Akira Kitamura¹, Sachiko Yuno^1,2, Ai Shibasaki^1,2, Kayo Takeda^1,2, Fusako Gan^1,3, Makoto Oura^1,2, Johtaro Yamamoto¹, Masataka Kinjo¹ (1.Lab. of Mol. Cell Dyn., Fac. of Adv. Life Sci., Hokkaido Univ., 2.Grad. Sch. of Life Sci., Hokkaido Univ., 3.Sch. of Sci., Hokkaido Univ.)

TAR-RNA/DNA binding protein 43 kDa, amyotrophic lateral sclerosis, intrinsically disordered region, RNA-binding protein, Fluorescence imaging