Type I interferons impede CRISPR/Cas9-mediated genome engineering via reduction in guide RNA expression.

Mitsuhiro Machitani; Fuminori Sakurai; Keisaku Wakabayashi; Kosuke Nakatani; Kazuo Takayama; Masashi Tachibana; Hiroyuki Mizuguchi

[1P-0782] Type I interferons impede CRISPR/Cas9-mediated genome engineering via reduction in guide RNA expression.

〇Mitsuhiro Machitani^1,2, Fuminori Sakurai¹, Keisaku Wakabayashi¹, Kosuke Nakatani¹, Kazuo Takayama^1,3, Masashi Tachibana¹, Hiroyuki Mizuguchi^1,3,4,5 (1.Grad. Sch. of Pharm. Sci., Osaka Univ., 2.Inst. for Virus Res., Kyoto Univ., 3.Nat. Inst. Biomed. Innov. Health Nutr., 4.Glob. Ctr. Adv. Med. Engin. Inform., Osaka Univ., 5.Grad. Sch. of Med., Osaka Univ.)

CRISPR/Cas9, type I interferon, genome editing

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The 39th Annual Meeting of the Molecular Biology Society of Japan

[1P-0782] Type I interferons impede CRISPR/Cas9-mediated genome engineering via reduction in guide RNA expression.

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