Fine tuning of antibody specificity by mutations focused on framework residues

Junichi Nakayama; Takamitsu Hattori; Hikaru Nakazawa; Mika K. Kaneko; Yukinari Kato; Izumi Kumagai; Mitsuo Umetsu

[1P-0811] Fine tuning of antibody specificity by mutations focused on framework residues

〇Junichi Nakayama¹, Takamitsu Hattori¹, Hikaru Nakazawa¹, Mika K. Kaneko², Yukinari Kato², Izumi Kumagai¹, Mitsuo Umetsu¹ (1.Dept. of Biomol. Eng.,Grad. Sch. of Eng., Univ. of Tohoku, 2.Dept. of Reg. Innov.,Grad. Sch. of Med., Univ. of Tohoku)

Antibody engineering, Framework, Unusual residues, VH/VL interaction

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The 39th Annual Meeting of the Molecular Biology Society of Japan

[1P-0811] Fine tuning of antibody specificity by mutations focused on framework residues

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