[2P-0005] Point mutations occur preferentially in heterochromatin with an oxidative stress signature during iPSC reprogramming

〇Masahito Yoshihara^1,2, Ryoko Araki³, Misato Sunayama³, Kohji Nishida², Hideya Kawaji^1,4,5, Yoshihide Hayashizaki⁴, Masumi Abe³, Yasuhiro Murakawa^1,4 (1.Division of Genomic Technologies, RIKEN Center for Life Science Technologies, 2.Dept. of Ophthalmology, Osaka Univ. Grad. Sch. of Med., 3.Dept. of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, 4.RIKEN Preventive Medicine and Diagnosis Innovation Program, 5.Preventive Medicine and Applied Genomics Unit, RIKEN Advanced Center for Computing and Communication)

iPS cells, mutation, epigenetics, regenerative medicine, bioinformatics