The Molecular Biology Society of Japan

[2P-0005] Point mutations occur preferentially in heterochromatin with an oxidative stress signature during iPSC reprogramming

〇Masahito Yoshihara1,2, Ryoko Araki3, Misato Sunayama3, Kohji Nishida2, Hideya Kawaji1,4,5, Yoshihide Hayashizaki4, Masumi Abe3, Yasuhiro Murakawa1,4 (1.Division of Genomic Technologies, RIKEN Center for Life Science Technologies, 2.Dept. of Ophthalmology, Osaka Univ. Grad. Sch. of Med., 3.Dept. of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, 4.RIKEN Preventive Medicine and Diagnosis Innovation Program, 5.Preventive Medicine and Applied Genomics Unit, RIKEN Advanced Center for Computing and Communication)

iPS cells, mutation, epigenetics, regenerative medicine, bioinformatics

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