[2P-0501(2PS15-7)] Contribution of Jagged1/Notch Signaling to Fibrotic Liver Regeneration through Possible Dedifferentiation of Mature Hepatocytes

〇Yasuhiro Nakano^1,2, Sachie Nakao^1,2, Hideaki Sumiyoshi^1,2, Kenichiro Mikami^2,6, Yuri Tanno², Minako Sueoka², Daigo Kasahara^1,5, Hiroshi Kimura⁵, Tadashi Moro^1,7, Akihide Kamiya^1,3, Katsuto Hozumi^1,4, Yutaka Inagaki^1,2 (1.Cent. for Matrix Biol. and Med., Grad. Sch. of Med., Tokai Univ., 2.Dep. of Regen. Med., Tokai Univ. Sch. of Med., 3.Dep. of Mol. Life Sci., Tokai Univ. Sch. of Med., 4.Dep. of Immunol., Tokai Univ. Sch. of Med., 5.Dep. of Mech. Eng., Tokai Univ. Sch. of Eng., 6.Dep. of Gastroenterol. and Hematol., Hirosaki Univ. Grad. Sch. of Med., 7.Res. Lab., Minophagen Pharm. Co., Ltd.)

Notch, Jagged1, Liver fibrosis, Hepatic progenitor cell, Hepatic stellate cell