[2P-0575] Systemic overexpression of SQSTM1 accelerates age of disease onset and reduces survival in SOD1^H46R mice

〇Shun Mitsui¹, Asako Otomo¹, Masahisa Nozaki¹, Suzuka Ono¹, Kai Sato¹, Ryohei Shirakawa¹, Hiroaki Adachi², Masashi Aoki³, Gen Sobue⁴, Hui-Fang Shang⁵, Shinji Hadano¹ (1.Department of Molecular Life Sciences, Tokai University School of Medicine, Isehara, Japan, 2.Department of Neurology, University of Occupational and Environmental Health School of Medicine, Kitakyushu, Japan, 3.Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan, 4.Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan, 5.Department of Neurology, West China Hospital, Sichuan University, Chengdu, China)

SQSTM1, ALS, SOD1